This is the Most Important Sperm Parameter To Diagnose Male Infertility aslo known as "SPERM DNA FRAGMENTATION TEST". Sperm DNA fragmentation test is a test to determine damage occurring during spermatogenesis , apoptosis in the seminiferous tubule epithelium, defects in chromatin remodeling during the process of spermiogenesis, oxygen radical-induced DNA damage during sperm migration from the seminiferous tubules to the epididymis, the activation of sperm caspases and endonucleases, damage induced by chemotherapy and radiotherapy, and the effect of environmental toxicants transport through the reproductive tract. The need to diagnose sperm at a nuclear level is an area that needs further understanding so that we can improve treatment of the infertile couple.
Recently, there is increased emphasis on sperm quality. This is due to the fact that Semen Analysis by itself is of limited value. Sperm is like a very small container with a large amount of DNA crammed inside. DNA is a protien structure that carries all the essential information. The Sperm DNA is susceptible to damage during its journey from site of production to its arrival at egg.
“OTHERS” Cell nuclei which do not correspond to spermatozoa.